CAREFLOX (Ofloxacin 200mg)

CAREFLOX (Ofloxacin 200mg)

Careflox is a synthetic broadspectrum antibacterial agent belonging to the fluoroquinolone group. The mechanism of action of Ofloxacin involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Careflox ensures:

• Outstanding efficacy against Chlamydia – potent in P.I.D.
• Highly bioavailable and deeply penetrated into various tissues.
• The combination of rifampin administered orally plus careflox is a suitable alternative to the conventional long-term intravenous therapy for treatment of orthopedic implants infected with staphylococci.
• Careflox is as effective as intravenous cefotaxime in uncomplicated spontaneous bacterial peritonitis. Nonazotemic cirrhotic patients with uncomplicated community-acquired spontaneous bacterial peritonitis and without hepatic encephalopathy have an excellent prognosis and may be treated with Careflox without requiring hospitalization.
• Careflox is useful in the treatment of patients of lungs tuberculosis.
• MDR-TB patients can be treated effectively with careflox.
• Safe and effective alternative of ciprofloxacin againt anthrax.
• Shows minimal interactions with drugs like theophyllin, cyclosporins and warfarin.
• Effectively treat pneumonia and bronchitis caused by Haemophilus influenzae and Streptococcus pneumonia.
• Most active quinolone against Chlamydia trachomatis.
• Drug of choice for acute bacterial diarrhea.
• FDA approved for the treatment of RTI, UTI, SSTI & pelvic inflammatory disease.
• Standard antimicrobial therapy for treatment of community-acquired pneumonia.
•  Better absorbed than Ciprofloxacin & Norfloxacin.
• Exhibits high tissue concentration, Intracellular concentration, adequate level in bile & faeces.
• Extraordinary activity against Gram-positive, Gram-negative & atypical pathogens.

INDICATIONS:

• Respiratory tract infections like lung abscess, aspiration pneumonia, empyema and bronchiectasis      
• ENT infections like chronic sinusitis, chronic suppurative otitis media,
  cholesteatoma and mastoiditis.
• Orofacial and dental infections.
• Dermatological infections like cellulitis, breast and other cutaneous abscesses, gangrene, diabetic and decubitus ulcers.
• Ulcerative gingivitis
• Trench mouth
• Vaginosis
• Malodorous tumors & ulcers

DOSAGE AND ADMINISTRATION:

The dosage is one tablet twice daily for 5 days.

CONTRAINDICATIONS:

Hypersensitivity to either quinolone group or nitroimidazole group.

SIDE-EFFECTS:

Common side effects include nausea, abdominal pain, vomiting, insomnia, dizziness, vertigo, ataxia, and mental confusion and hypersensitivity reactions. Leucopenia has also been occasionally reported.

INTERACTIONS:

Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Antacids reduce the absorption of Ofloxacin.

WARNINGS AND PRECAUTIONS:
Pregnancy: Should not be used in pregnancy.
Nursing Mothers: No adequate trials are available to suggest the administration of either drug during breastfeeding.
Paediatric Use: Although many authors suggest contraindication for the use of Fluroquinolones in children, in the light of clinical experience other recommend a cautious use of these drugs as and when necessary in children.
CNS Stimulation: Ofloxacin can cause CNS stimulation and therefore the drug should be avoided in CNS disorders like epilepsy and cerebral arteriosclerosis.
Renal or Hepatic Impairment: Administer with caution. 

Packing: alu-alu (10*10)

M.R.P.: Rs. 4.90/- per tablet